Hi! I was 1st dx'd with MDE in 1994. I did pretty well most of the time until June 2006. Since then I have really been struggling to find the right meds.

Serotonin syndrome-mild, when Zoloft increased while on Trazodone. Went off zoloft.

Also went through trials of meds for ADD-bad reaction to Strattera because of heart defect. Trials of Cymbalta, Lexapro, Wellbutrin, didn't work, but don't think the 2 weeks my doc gave them was enough time and my gastritis-undx'd then, made me think the meds were causing problems. Really struggled to stay on keel, but got very bad in late July. Went on zoloft 50 mg, and got a little better-but doc added 60mg Cymbalta and I was put on Prilosec for gastritis.

This is were the fun began--I take antihistamines for allergies and it slowed my reaction. I thought I had a faint red rash for a week, then one day, most of my body was covered with a bumpy red rash, some like bright red blood blisters, terrible itch, leg and face swelling, sore tongue/throat, swollen tongue and tingling lips.

Stopped the prilosec after reading about interactions-took benadryl and the symptoms were reduced. Switched to zantac-and back to the rash etc. Off the zantac, a bit better, but when I forgot my benadryl, the allergic reaction came right back-so it had to be the Cymbalta.

Went off of it cold turkey-staying on zoloft. Switched docs because 1st one did not call back when I reported the allergic reaction. New doc put me on Celexa, 10mg to start one week ago today-10-11. I also take 54mb Concerta-3 years and ritalin 10mg taken at noon, 3, and 6pm because concerta wears off and I drop with fatique-have fibromyalgia too.

The Cymbalta worked well for my depression and fibro. Since stopping it, I have severe muscle fatigue and pain, I am anxious again, crying for no reason, get upset over nothing, and just feel like I am going downhill.

Is this treatment resistant depression? Or do I need more Celexa, a different med, add buproprion, or what?

I am so tired of fighting this and need to find a treatment plan that works. I have never struggled this much for so long. I just want to be well and function without feeling like I will fall apart at any second.

Thanks for reading this long post and helping-I am at wit's end.