Emsam has almost no side effects. At first I had some skin reactions to the patch but they changed the adhesive and never break out now. It is a little stimulating but not a problem at all. The first few weeks I needed some extra PRNs but that was it. I even lost weight on it until I had to be on more Seroquel. It's been a great drug for me and continues to work great for 7 years. My pdoc says it doesn't seem to poop out. There is the MAOI thing but at the low dose you don't have any restrictions. My dr doesn't make me follow much restriction (just caution and common sense about how much I consume) b/c she talked to the man who developed it and he told her the FDA only put restrictions on that dose because they were afraid of an MAOI without restrictions). On the high dose I follow restrictions but I've not been on the high dose much.

It's a wonder drug for me. It and clozaril have saved my life.