I have been on topamax for 10 years now. Treatment for Bipolar in combination with other meds. I would say it is a medication that works for me. I have taken it at high doses 300mg twice a day which I would not recommend as this gave me tremors, short term memory loss, and aphasia.

Currently I am on 75mg twice a day and I can honestly say I don't experience any side effects that I notice.