Unfortunately what you are experiencing with discontinuing Effexor is common. Effexor does not remain in the body all that long, so missing a dose or taking a lower dose in just one day can cause ill effects. I've been taking Effexor for about 5 years and fortunately have never had problems. Although I have never attempted to discontinue the medication nor do I have any intentions to. Some patients are more sensitive to dose changes than others. My suggestions is to keep your doc informed of what you are experiencing and closely follow his/her instructions.