They've done studies that show the more/longer you do it, the stronger the neural pathways for equanimity, compassion etc.
In terms of instant calm or whatever, I find results vary depending on what I use. Current fave is iRest, which is designed for PTSD.
I definitely notice better sleep if I do it at night, regardless of method.
Sometimes my mind/nervous system is too messed up for meditation and I need to do something physical like yoga instead - also a form of meditation.
I know the times I practice routinely, I feel way more solid and less reactive. Much more able to deal with life. But it's a commitment, that's for sure. And hard for the more impulsive of us to discipline ourselves into.
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