Hello Manqueman: Yes, there certainly are people for whom neither therapy nor antidepressants (or other psych med's) are helpful. The Skeezyks is one of them.

In my case, I have simply organized my life, as much as possible, to coincide with my mental health issues. I'm as reclusive as it is reasonably possible for me to be. I employ a meditation practice. And I do a variety of other things that help me to carry on without resorting to therapy or psych med's. I am fortunate though in being an older person. So I no longer am forced to be out in the world pursing gainful employment, socializing, etc.
I see this is your first post here on PC. So... welcome to PsychCentral… from the Skeezyks!

I hope you find the time you spend here to be of benefit.
PsychCentral is a great place to get information as well as support for mental health issues. There are many knowledgeable & caring members here. The more you post, & reply to other members’ posts, the more a part of the community you will become. Plus there are social groups you can join & chat rooms where you’ll be able to connect with other PC members in real time (once your first 5 posts have been reviewed & approved.) Lots of great stuff! So please keep posting!