I have been on and off of antidepressants for 15 years and most of them had no effect on me. The one or two that did work eventually wore off after a few months. It was a risky investment for me to purchase a device like this one, but now I am so glad that my doctor told me to look into this. Not only do I not have to take medication anymore, which may cause side effects and dependency issues, but it ends up being a lot cheaper in the long run. Although my depression is not completely cured, I find that there has been a significant decrease in my sad spells. I sleep much better, and I am much less irritable with family. My depression is managed much better and much more consistently with the Fisher Wallace stimulator, and I am so glad that I took the plunge to actually buy it!