I take a similar cocktail and find it to be very beneficial with few side effects. I take the wellbutrin. Dexedrine instead of the adderall. For sleep I sometimes take trazadone or rozerem. Oh, yeah I also take lamictal as a mood stabilizer. I am not really concerned that I am on too many drugs. Each of them are prescribed for a different reason. I have been on this cocktail or similar ones for several years. I am much better off being on the medications!!!