I feel like mine is a chemical problem in my brain. My depression is atypical in that, while I hear from a lot of other people that when they are diagnosed, they realized it had been something they had struggled with their whole lives. My depression hit me in my late thirties and it felt unique in that it was a new experience for me.

My upbringing and history has a clear and definite impact on my depression. Living a life in the closet for so long had directly led to my feelings of lonliness and inability to find a relationship. But when the depression hits, for me it definitely feels "chemical" in nature and a skewing of what is real and what is a creation of my brain.

I definitely believe that history can create a state of depression. I think in some people it may be 100% chemical in nature. For me and maybe for most a combination of the two.

I think this is an important topic. For some therapy alone can be a solution for depression. For other a combination of therapy and medications. It depends on the root. Thank you for posing this question Eamgr it is something I think about often.