Yep, like Crazy Hitch said, during Mixed Episodes. Those are theeee worst!!! It's made all the more extreme if I take a percocet for pain (lumbar fusion). I'm the kind of person that opiates and opioids do not knock out... I get "activated" and mildly euphoric. It's almost like a mania. I can get a lot done, or so I think. But the sadness and depression is always there underneath. There are times I am naturally happy and cheerful, but come to think of it, those days are fewer and further between.