Brintellix, now called Trintellix has many of the side effects of the SRIs
Quote:
Sexual Dysfunction
Difficulties in sexual desire, sexual performance and sexual satisfaction often occur as manifestations of psychiatric disorders, but they may also be consequences of pharmacologic treatment. In the MDD 6 to 8 week controlled trials of TRINTELLIX, voluntarily reported adverse reactions related to sexual dysfunction were captured as individual event terms. These event terms have been aggregated and the overall incidence was as follows.
In male patients the overall incidence was 3%, 4%, 4%, 5% in TRINTELLIX 5 mg/day, 10 mg/day, 15 mg/day, 20 mg/day, respectively, compared to 2% in placebo. In female patients, the overall incidence was < 1%, 1%, < 1%, 2% in TRINTELLIX 5 mg/day, 10 mg/day, 15 mg/day, 20 mg/day, respectively, compared to < 1% in placebo.
Because voluntarily reported adverse sexual reactions are known to be underreported, in part because patients and physicians may be reluctant to discuss them, the Arizona Sexual Experiences Scale (ASEX), a validated measure designed to identify sexual side effects, was used prospectively in seven placebo-controlled trials. The ASEX scale includes five questions that pertain to the following aspects of sexual function: 1) sex drive, 2) ease of arousal, 3) ability to achieve erection (men) or lubrication (women), 4) ease of reaching orgasm, and 5) orgasm satisfaction.
The presence or absence of sexual dysfunction among patients entering clinical studies was based on their ASEX scores. For patients without sexual dysfunction at baseline (approximately 1/3 of the population across all treatment groups in each study), Table 3 shows the incidence of patients that developed treatment-emergent sexual dysfunction when treated with TRINTELLIX or placebo in any fixed dose group. Physicians should routinely inquire about possible sexual side effects.
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table 3: ASEX Incidence of Treatment Emergent Sexual Dysfunction*
View Enlarged Table
TRINTELLIX 5 mg/day
N=65:67† TRINTELLIX 10 mg/day
N=94:86† TRINTELLIX 15 mg/day
N=57:67† TRINTELLIX 20 mg/day
N=67:59† Placebo
N=135:162†
Females 22% 23% 33% 34% 20%
Males 16% 20% 19% 29% 14%
*Incidence based on number of subjects with sexual dysfunction during the study / number of subjects without sexual dysfunction at baseline. Sexual dysfunction was defined as a subject scoring any of the following on the ASEX scale at two consecutive visits during the study: 1) total score ≥ 19; 2) any single item ≥ 5; 3) three or more items each with a score ≥ 4
†Sample size for each dose group is the number of patients (females:males) without sexual dysfunction at baseline
Link:
Trintellix (Vortioxetine Tablets) Drug Information: Side Effects and Drug Interactions - Prescribing Information at RxList
Some other links about Trintellix::
Vortioxetine - Wikiwand
Just like all serotonergic drugs, it has the possibility of causing sexual side effects. Yes, some pdocs add wellbutrin - DA,/NE reuptake inhibitor, to help with the side effects. If used together Wellbutrin will increase the effects of Trintellix by up to two fold:
https://www.drugs.com/interactions-c...-18003,440-203
Quote:
Chen et al12 carried out multiple studies in healthy human
volunteers to evaluate potential pharmacokinetic interactions
between vortioxetine and coadministered agents with
a range of activity as inhibitors, inducers, or substrates for
CYP450 subtypes. They identified potentially significant
interactions in the form of increased vortioxetine levels
when it was coadministered with bupropion (CYP2D6
inhibitor and CYP2B6 substrate), fluconazole (inhibitor of
CYP450 2C9, 2C19, and 3A), and ketoconazole (CYP3A and
P-glycoprotein inhibitor) and decreased vortioxetine levels
when it was coadministered with rifampicin (CYP inducer).
The authors considered that only the interactions with
bupropion and rifampicin were likely to be sufficiently
significant to warrant possible dosage adjustment. The US
datasheet (http://www.accessdata.fda.gov/drugsatfda_docs/
label/2013/204447s000lbl.pdf) recommends reducing the
dose of vortioxetine when giving it in combination with
powerful CYP2D6 inhibitors such as bupropion, fluoxetine, paroxetine, and quinidine, and increasing it when it is administered
in combination with powerful CYP inducers such as
carbamazepine and phenytoin
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This is from a paper that goes into greater detail overall about vortioxetine
http://s3.amazonaws.com/academia.edu...idepressan.pdf.
If you want to read more in depth information. This paper goes in the chemical properties, mechanism of action, pharmacokinetics, drug interactions, and studies.
Vortioxetine (Brintellix): A New Serotonergic Antidepressant
Talk to s/he about the interactions between the two. The amount of Pristiq and Trintellix used is important. Since they both work on 5-HT there is a chance of people getting serotonin syndrome but your pdoc should know this and adjust the doses accordingly. Drugs.com claims used concurrently as possible major risk but that is a very cautious overview. Ultimately it is your pdocs knowledge and yours also that is most important.
Hope this helps and of course talk to your health care providers and pdoc about your issues, concerns, and options, as it's all about your health and happiness.
Here are some anecdotal reports about the two used seperatley and in combination
https://treato.com/Pristiq,Trintellix+(Brintellix)/?a=s