I am Bipolar I with ultradian cycling. I have been on Seroquel for most of the 15 years since initial diagnosis. I had tried Risperdal and Zyprexa prior to starting Seroquel. I have tried small doses of Risperdal, Latuda, and Rexulti for short periods of time with my 800 mgs of Seroquel, but those combos were mostly not effective or there were too many side effects. Several months ago my pdoc added a pinch of Abilify to my Seroquel and I felt a difference with the intensity of my moods. Now I have decreased Seroquel to 600 mg and increased Abilify to 7.5 mg. I may be able to get off Seroquel and replace it with Abilify eventually but for now I continue to take both. Have others had success with taking 2 atypical antipsychotics at the same time? Were there significant side effects of such combos? Did anyone manage to transition to just one antipsychotic over time? Thanks for any feedback.