If I go a day without Seroquel, I certainly notice it, since I cannot really sleep without it....with the exception of times where I drink too much (which tends to be my reason for not taking it). It throws me off for a day or two and makes me feel extremely groggy, irritable, and I get intrusive thoughts. If I drank the night before, of course that makes it so much worse.

With Lamictal, I take one AM and one PM pill. I usually do not notice the first missed dose. However, if I miss two pills, I get much moodier. When I miss doses, it's definitely a wake up call for me and a warning sign that it's time to take better care of myself. Remembering that and putting my health first usually gets me back on track again. I especially try to be careful about not missing Lamictal since I see seizures is a risk as a withdrawal symptom.