Some meds have certainly triggered episodes for me. Both going on them and coming off. My T has noticed this. I have to be monitored closely whenever I change meds. For example going on some AD's can make me hypomanic and going off them can make me mixed. However, right now I am a month into being on Cymbalta and it has not made me hypo at all. I am still depressed and exhausted but maybe slightly better. Meds are weird. We never know how we will react.