Thanks for the information! I have some hope for the ketamine/esketamine. From what I read, the trials to date yield mixed results, but enough positive response to warrant more study. Sedation/disorientation might be a problem for some. I'm not ready to try this, since I really struggle with fatigue already. But at some point, with enough information and convincing positive results, it might be worth a second look and a try. I like that research is trying to find different approaches with the brain chemistry. So many of us need help from new directions.