Seroquel has some awful side effects (sleepiness [for me, including the next day, I take it at night], hunger and potential weight-gain). But I've had two pdocs now swear by it, that it helps with both depression and mania, with insomnia, and for acute mania it can bring you down pretty quickly.

I used to hate taking it, but now I do see that the pros outweigh the cons and have made my peace with it.

Best of luck in your decision!