I did this a year ago when I switched to Emsam (which doesn't work anymore, ha). I had to go off everything except Xanax XR. I didn't have to go inpatient and I saw my therapist and psychiatrist more frequently during the 2 week period when I wasn't on anything. I also kept going to work. I would say the worst parts of it were extreme fatigue, hypersensitivity to noise, and I had a short temper.