I have been on Topamax 400mg a day seems to help a little with the mood swings but is hell for depression and anxiety so they put me on Buspar 60 mg in the morning and 60mg at night plus 10mg of Ambien at night. I still can't sleep, suicidal thoughts constantly, really irritable and angry, not to mention being in a constant dreamy state. I talked to my General Practitioner and he said keep taking the medications for a few weeks and see if the side effects fade and the Nurse Practioner that prescribed them said it will take a while for them to take full affect. They said they gave me such a high dosage so it would be effective because my anxiety and panic is so bad. With the Topamax my depresison has been out of control and really severe then they add these medications to treat my GAD and it makes me feel like I am in a fog all day long and I don't get out of bed. I don't know what to do, I have talked to a few different doctors and they said there is nothing else they can do except try me on medications until they find the right combinations. My depression isn't even being treated yet because they want to treat the worse symptoms first. I have a 6 year old and a 3 year old, I'm not sure how much longer I can go through these medication cycles. I can't take care of them when I am in this state but without medication I know I'm not going to be very productive either. At 18 a psychologist took me out of high school b/c of my mental health, I had to quit 2 jobs and got fired from one because of thee problems, and I have been unable to work since 2002. And on top of it all my physical problems require me to be on Metformin 1500mg a day, Lisinopril 20 mg a day, Lipitor 20mg a day, prescription Ibuprofren 2400mg a day for knee and back pain, Singular 10mg, Albuterol Inhalor 4 to 6 times a day, Advair inhalor 2 times a day, and Xopenex Inhalor 4 to 6 times a day. I feel horrible all the time and my depression seems to get worse.