I had a bad experience with pristiq. Pushed me into dysphoric hypomania which only got worse upping the dose to 100mg. It was monotherapy at the time (prior to bipolar dx) which was probably the main reason it sent me batty. We later added lithium but I was too far into the episode by then, I had an improvement then got sick from lithium, stopped taking it & kept taking pristiq & things went haywire in the worst way. I did sweat but it was no big deal. We're all different tho, good luck, don't let my experience scare you.