Yes, there has not been a time within the last four-plus years that I haven't been taking more than one. For the last 9 months it's been

Lamotrigine (Lamictal) 200mg /day
Nefazodone (Serzone) 600mg /day
Buproprion (Wellbutrin) 450mg /day

Two weeks ago pdoc prescribed a new one called Vraylar (caraprazine) .75mg /day. Technically it is off label - it is nominally for bipolar and schizophrenia - but so far it seems to be having a positive effect for me beyond placebo. (I'm your basic treatment-resistant depression and/or dysthymia, depending who's doing the diagnosis, so we'll see how it holds up.)

Other than that, the Wellbutrin (buproprion) has some beneficial effect, though it waxes and wanes. The other meds, no effect I can tell, but for now I have no reason to reject them, as they have very little side effects, so for the moment I defer to pdoc's judgment as to efficacy.