Hi bebe,

My pdoc was the one that put me on SAM-e since absolutely no anti-depressants worked. The only thing I was on along with is was Valium for my anxiety. I took it for over a year with no results that I could feel. At least with SAM-e, I didn't have any side effects either, but no effect in how I felt either. Herbal/natural meds have had the least bad effects of everything for me, but never had a positive effect either. At least I wasn't suicidal at the time since status quo in that state wouldn't have been good either.