I've been on Seroquel for a few years now. It only costs me about $15 for a 30 day supply and about $25 for a 90 day mail order supply. I've never been on Latuda. Seroquel is super sedating, so I make sure I take it early enough at night so that I do not have the "hangover" effect in the morning. It usually does not make me tired during the day if I follow that rule of thumb. If I take it too late and have to wake up early, it does give me that "zombie" feeling, so I'm working on getting better about taking it at the same time each night. Lately, I feel fine on it. Seroquel has a calming effect on me. I did not gain any weight, although some people do. Overall, I find it a good medication for me.