I don't know if depression becomes untreatable over time, but I do know that I had depression for close to 40 years and bipolar for over 25 years when I went off meds and started treating myself using amino acids and the mineral supplement lithium orotate. When I was on meds for 13+ years, my moods were subdued more than controlled as meds seem more to sedate and zomphify most people.

Now that I'm on amino acids and lithium orotate, my mood is good--I'm happy without being hypomanic, my life has purpose which it certainly didn't when I was on meds as I was very depressed most of the time and feeling worthless. It's nothing short of a miracle the difference using alternative treatment has made in my life!!

The thing people need to understand is that meds like antidepressants don't enable the brain to produce neurotransmitters that keep the mood stable. What they do is keep the neurotransmitters that are there from being reabsorbed as they're supposed to so they end up old and stale and not able to do their job. I like to think of this as being on a long flight breathing recirculated stale air. I believe [and this is strictly my personal opinion based on my experience and research] that people with mood disorders aren't able to produce the neurotransmitters needed to keep our moods stable and happy. I think of it like juvenile diabetes where the child has to take insulin because his pancreas doesn't produce it. That's how I see my brain--it needs to be given the amino acids and lithium orotate to keep my mood stable.

Here are a couple of articles about using amino acids to improve your mood:

https://experiencelife.com/article/a...-improve-mood/
http://www.naturalnews.com/034030_am...addiction.html

This is a brain function questionnaire showing what emotions and feelings are linked to which neurotransmitters.

http://drjolee.com/Brain-Function-Questionnaire.pdf