Depends on how much and how often along with what your doctor says. For awhile I was taking 2mg 3x a day (so 6mg daily) per doctor's orders. People often asked how I got off that, and I don't know, it was easy to get down to 2mg. I got down to 1mg but then things got crazy so I went back up to 2mg and pdoc says just leave it for now we'll deal with it later.