I live with chronic daily pain and sickness. When I am manic, I still have pain but it's much reduced from normal. When I'm stable I have pain but it doesn't mentally rip me up. I can cope, though it is hard.... When I'm depressed I feel that life isn't worth living because of this chronic pain and it really brings me low and I feel the pain more intensely. It's another big component in my illness actually. I think it's why I especially enjoy mania, even if I'm paranoid and anxious....it still feels better than usual somehow.