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Now, this notion of the “chemical imbalance” has been much in the news lately, and a lot of misinformation has been written about it—including by some doctors who ought to know better 2. In the article I referenced, I argued that “…the “chemical imbalance” notion was always a kind of urban legend—never a theory seriously propounded by well-informed psychiatrists.”1 Some readers felt I was trying to “re-write history”, and I can understand their reaction—but I stand by my statement. Doctor, Is My Mood Disorder Due to a Chemical Imbalance? | World of Psychology
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For another discussion of causation of depression, see:
Causes of Depression: Genetics, Illness, Abuse, and More
The perplexity about the complexity of mental disorders is very real.