I've taken it in the past on its own and it's made me Hypomanic/manic. I'm now taking an AP and decided I wanted to try welbutrin along with it. I'm only taking 100mg and the first few days I felt a little hypo....but now it's easing up. We shall see what happens. Welbutrin has worked better for my depression than any med I've yet tried so I'm hopeful the AP will keep me from going in the manic direction.