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I've been on anything between 25 and 900 mg. Interestingly enough, the increased dosages had less side effects in terms of drowsiness and weight gain.
Don't worry, climbing above your 450 mg dose will be fine.
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Meds: Latuda, Lamictal XR, Vyvanse, Seroquel, Klonopin
Supplements: Monster Energy replacement.  Also DLPA, tyrosine, glutamine, and tryptophan
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