I decided to try estrogen and progesterone in a patch form instead of an SSRI. It works. I'm not depressed or having rage anymore. I also have increased libido. I wanted to avoid the notable SSRI negative sexual side effects. With hormones sex is great. I discussed this idea with my pdoc. I told him i was tired of conventional psyche meds and I wanted to see if my hormones needed adjusting. So far so good. I do still take Seroquel and Topamax but have avoided the SSRI. If you are in your forties you may want to consider hormone replacement therapy in lieu of SSRIs.