When I filled my rx the pharmacist said I would likely experience sedation but I've not had any sedation at all from lamotrigine. In fact I feel more energetic the higher the dose gets, I'm only at 50mg so far, & titrating up 25mg every 2 weeks, which is actually slower than my neurologist instructed but I've been scared off of faster titration because of the stories of Stevens Johnston syndrome (SJS) or the dreaded lamictal rash. I've actually nursed a patient who developed toxic epidermal necrolysis (TEN), the most severe form of lamotrigine skin reaction & she essentially appeared to have severe burn scars, all over her body. Poor woman was traumatised for life & still struggled with the pain the scars caused, not to mention the psychological pain she's suffered as well.