Yea my last dosage was 300 and I didn't sleep more than 2 hours. It was bad. Saphris used to work for me but it just doesn't anymore. It takes a lot to put me out. I've tried supplements, OTC meds, meditation etc. I've tried it all. Right now I'm just barely hanging on and sipping caffeine all day. I've been on seroquel for sleep for 12 years now. It really is the only thing that works and I'm frustrated.