Changing medication is always very difficult; even when the pharmacy changes manufactures. I can remember when my pharmacy told me that they had to change manufactures and it was because of that choice that I had to change pharmacies. I took Mirtazapine and I did not want to change manufactures because it gave me heart palpate strongly and it also made me sick. So, I researched other pharmacies and found Target pharmacy to stay with the same manufacture that I had before for the Mirtazapine. When you are changing medications, I would ask your doctor and or pharmacist and do lots of internet research. I have been taking this drug for about 14 years and it has helped me a lot, but I still had to ask questions and I continue to do so. Good luck to you.