Get rid of anything you haven't worn or used in a year. You have to keep your "stuff" clean, so why have it if you don't need it?

All you have to do is pick an area and bag what can go to Goodwill.

Then pick any room in your home and start on that one. I have found these cleaning wipes that work on any surface to be well worth the money when those times are such that I can't find the tv... :-/
Just walk around wiping....