I was taking the top rated Probiotic for years with no positive results on my IBS or mood. My son was taking them for years too (they had the best and most complete forms of bacteria and were much stronger than OTC versions. It was called VSL. We spent fortunes on the stuff over the years and my sons gastroenterologist told me that studies indicate it's not truly effective and told me to stop wasting my money. Science and studies change all the time however. I've read many pro vitamin materials, books and articles as well as well respected scientists who dispute their effectiveness and encourage getting vitamins in the form of whole and healthy foods. I get confused and buy into each theory depending on the day, my mood and how much extra money I have to spend on supplements which may or may not work. Lots of schools of thought on this topic and I'm very glad there are people whose illness responds well to these treatments. A doctor I talked to earlier this year who I told about the supplements I was taking and how I preferred natural methods and eating well to typically prescribed medications flat out said "that's not going to work, you have bipolar". She was confident that active bipolar cannot be treated with natural medications. Some days I believe her, others I just get so confused and ready to start spending hundreds a month on supplements again. I really can't afford it now so it's not even an option. I will try again once money isn't so tight. Quality fish oil seemed to help but it's so expensive to get the kind they claim actually works.