I've taken klonopin every morning with the rest of my morning meds for some 10 years now. It's hard to know how that has affected me since I take so many other meds and have taken it for so long. But more recently, my pdoc has prescribed more, to take PRN, when I feel I'm going to have a panic attack and feel paralyzed and can't get up to do anything. So this is the first time I've taken it, say, in the afternoon, away from other meds. Contrary to making me feel depressed, I feel like it frees me from the panic and the ensuing feeling of paralyzation (sp?) and allows me to get up and do what I need to do. No feelings of depression there.