Absolutely!! I was on it for years and very seldom not borderline depressed. I then went off all meds but decided later to go back on klonopin because of a crazy sleep disorder. Within 3 days I was sobbing uncontrollably [and I'm not one to cry much] for days on end for no reason. I realized something was very wrong when I started seriously considering how to kill myself. My sister had been told by a neurologist that antidepressants cause anxiety so I wondered if klonopin might being causing the suicidal thoughts so I googled it. Sure enough, there it was! I went off it, and within 3 days was fine again.