I just started taking Lamotrigine about a month ago. I know sometimes it can take awhile for things to really take effect, but I do feel at least somewhat better. Also, I'm taking Bupropion (Wellbutrin) but that has been decreased from 300mg to 150mg, whereas my Lamotrigine has been increased from 50mg to 100mg. It's all trial and error it seems. And like someone else said, what works for me may not necessarily work for you or someone else.