Hey. For most of the year this is the difficult time of the day - 3-6 (hypo-mania and mixed state). My seroquel wears off. My strategy is in place. Which is to say and interact as little as possible until until the after-work dose kicks in. FYI, I've tried several strategies with Seroquel and Seroquel XR. There's always a gap of a couple of hours because I can't take it at work. It sometimes intoxicates me a bit.