I take 30 mirtazapine and should take 100mg sertraline but the 100 wired me up so i cut to 50mg. that combo 30mirt 100 sertraline. my shrink say was the furthest he go with me being over 65 or i could risk serotonin syndrome. believe this i had serotonin syndrome in the hospital when they added TRAMADOL to my meds