I don't have any official dx of a personality disorder. I know I am close to several. I do take welbutrin for obsessive thoughts. At higher doses, it changed my personality considerably; so I do believe that medication can make a change to someone. That being said, they are not always good changes, as I became antagonistic and ready for a fight on the higher dose. On one hand I liked it because I didn't care what others thought of me so much and I was able to stand up for myself more. On the other hand, I really didn't feel like me anymore.

Also, I tried a break without it and over about a 4 month period of time, I spiraled down to the worst depression I have ever been in. I had major life stuff hit me. Since life stuff always happens; I've wondered if my inability to deal with what happened was because I was off the medication. Even going back on it.. it has taken a year to get me to where I am feeling pretty good about life and able to handle the hard days.