tramadol is unique because it works as an opiod and it also works on serotonin. this is most likely why you feel your depression lifting. however, tramadol is addictive, and your tolerance to the medication will increase...meaning you will eventually need to take more to get the effect you desire. tramadol withdrawals are not fun because as i stated, it is not just a pain med. it would be like withdrawing suddenly off of an anti-depressant and a pain med at the same time. i am speaking from experience