Sounds very frustrating.
Generally speaking, spouses participating in our healing efforts have our best interests at heart, even if misunderstanding something. Same with best friends.
It's interesting that all 3 -- your spouse, your best friend and your doctor -- disagree with you. Why?
Find out more about why your husband and best friend have the opinions they have shared.
Clarify what's on the line, especially with your husband. Let him know what's on the line from your viewpoint. Find out what's on the line from his viewpoint. Talk it through and reach an agreement for med trials -- or maybe don't negotiate and possibly agree to separate?
The bottom line is you need whatever you need. Be as clear as possible about your own needs.

WC