If we had a pot of stew with a sour taste or maybe it was too spicy or it simply had no flavor at all, would we have a broken stew or a stew with a chemical imbalance...or...or what? I used to read the PDR (Physicians' Desk Reference, a compilation of manufacturers' prescribing information on prescription drugs) whenever something was prescribed for me -- Thorazine was my first -- and it always bothered me that the mechanism of action was almost never known. Things turned out well when a chemist trying to invent a strong aerospace adhesive accidentally discovered Post-It notes, but throwing more spices at a pot of stew to see what happens when it hits the palate is just not something I want done with my brain. Today I do take a med that does make a huge difference for me in the depression department, and it is like icing on the cake to know exactly why the med works and that my brain never did need to be mushed.