Yes I actually heard acne is a side effect and I'm already prone to cycstic painful acne but it's cleared a lot since I'm hitting 30. I've spent so much money on supplements this past few months so I hope this one works. The 5-htp made me more moody because I'm sensitive to serotonin like ADs but L-tyrosine is a keeper. Next fri I'm ordering theanine for anxiety and the LO. Excited to try both! I'll keep ya posted.