When I have migraines it's always during periods of stability.
It may be lack of tension or due to anxiety. Muscles, nerves, blood vessels, the immune system and anything that affects those can cause it, I guess.
Smoking or drinking coffee or more or less heat (or both) or anything increasing or acting as serotonin or epinephrine might help.
I only have migraines, but it's still likely something like that might help. And part of it might be purely psychogenic, (or rather, purely) mental, to substitute pain with pain.
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Mania kills cells. Brain cells die. Memories become more reduced conceptually, making more efficient use of limited means. Memories shape our reality. Our memories are more or less split in two by abstractions, conceptual reductions. Mood states with memories, concepts, attached. Memories of pain and those of joy. It causes instability, changeability. Fearing that will leave an emptiness between pain and joy and a greater divide.
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