I take Abilify (sort of like Rexulti, senior) at a high dose with a high dose (400mgs) wellbutrin, plus lamictal and trileptal.

The big issue I think is seizures, which can happen with a lot of psych drugs, but wellbutrin has a bad reputation. I think the current maximum dose for wellbutrin is 450mgs/day, but the seizure rate goes up after 400. Its weird like that.

I'm clearly not any kinda expert (I'm just weirdly, moderately, OCD-ish and fascinated by psych drugs, so I read about this stuff sometimes), but my vote is for the combination probably being more helpful than potentially harmful.

Antipsychotics/neuroleptics+lithium, though, can = more problems in some people. Not trying to scare you or whatever, just saying that if you get the tics and twitches and such, it might not be the wellbutrin+rexulti, but rather the lithium+rexulti. And, as always, during the first couple weeks of taking Rexulti, be aware of the NMS risk (rare, but has to be addressed promptly).

Hope things work out well for you.