I wish I could get along on one med, but I'm on six and need every one of them. But whether you're on one drug or ten, med compliance is essential. You can't just go on and off meds, if you do they can stop working and/or they might not work at all the next time. For me, it took a long time and a hospitalization to get the combo right...I'm not going to risk my stability by messing around with it.