I was on quite a cocktail of meds for several years. I had treatment resistant depression and after trying a whole bunch of meds, they finally just started adding them. When I googled my meds there were all sorts of warnings about the combos I was taking. I talked it over w pdoc, and was reassured and stayed on them for a couple of years. They didn't really help, but they don't seem to have harmed me either. I am slowly tapering off them. Down to 3!