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It can make you more depressed or more manic, in my experience. It's not like some stimulants that might cause mania when (severely) depressed. But it does increase the production and use of serotonin, (nor)epinephrine (and dopamine) and (brain) metabolism in general, but that doesn't always mean you'll feel better. It's not stronger biochemically than the strength of a psychological reaction to it is, at least, I believe.
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Mania kills cells. Brain cells die. Memories become more reduced conceptually, making more efficient use of limited means. Memories shape our reality. Our memories are more or less split in two by abstractions, conceptual reductions. Mood states with memories, concepts, attached. Memories of pain and those of joy. It causes instability, changeability. Fearing that will leave an emptiness between pain and joy and a greater divide.
See Me, Feel Me, Touch Me, Heal Me.
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