I took Zyprexa for a couple months 2 years ago or over 2 years ago. I only gained 4 or 5 lbs. It was for depression and it really worked! I felt great. I'm on invega and I feel it makes me more depressed, though that may not be true. I know Zyprexa is approved for bipolar depression and Latuda gave me so much anxiety and nightmares I had to stop it. The St. John's wort is helping, but I feel like if I need to pick an AP it should be Zyprexa. I know about the weight gain but I exercise multiple times a day. I am just hoping to get some relief from the lethargy and multiple naps, sleeping in, morning depression. I haven't decided if I should talk to my pdoc next week about it, but I start training for a job captioning with suicidal deaf people on January 3rd and I need to feel better by then or else it will be another failed work attempt. I don't want disability just yet. I could wait it out a little bit longer and see if the meds can help. Does Zyprexa make anybody lethargic? I was on a low dose so I didn't seem to be, but that was a long time ago. Anyone have any good experience with it? It seems like my last option before work starts.